Second-Near-Infrared Light-Induced SnSe Nanosheets for Augmented Photonic Tumor Hyperthermia.

Triple-negative breast cancer (TNBC) poses a serious threat to the lives and health of patients, as traditional treatments are limited by psychological burden, systemic toxicity, or drug resistance. Photonic hyperthermia triggered by the second near-infrared (NIR-II) window is a promising minimally invasive strategy. Herein, we synthesized SnSe nanosheets via a simple, scalable method for NIR-II-triggered photonic tumor hyperthermia. SnSe nanosheets exhibited irregular lamellar structures with uniform Sn/Se distribution, favorable biocompatibility, and prominent photothermal performance under NIR-II irradiation. Under NIR-II irradiation, the SnSe+NIR-II group significantly suppressed tumor growth. This work offers a platform based on NIR-II light-induced photonic tumor hyperthermia, providing a minimally invasive strategy for TNBC treatment.