Revista da Sociedade Brasileira de Medicina Tropical · 2020
AIDS-related progressive multifocal leukoencephalopathy.
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Abrão Carolina de Oliveira, Silva Lissa Rodrigues Machado da, Souza Luiz Carlos Silva, Bisso Nathalia de Mello, Turchi Marília Dalva, Guilarde Adriana Oliveira
Аннотация
INTRODUCTION: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by reactivation of JC virus (JCV).
METHODS: We described the profile of laboratory-confirmed PML cases among AIDS patients.
RESULTS: A total of 43 HIV patients with clinical conditions compatible with PML were obtained; 5 cases were confirmed by JCV testing. The main clinical finding was mental confusion. Median CD4 count was 54 cells/mm³.
CONCLUSIONS: Three of the five confirmed PML cases died; the time between diagnosis and death was 2, 5, and 6 months. It is important to consider JCV infection as a differential diagnosis.
METHODS: We described the profile of laboratory-confirmed PML cases among AIDS patients.
RESULTS: A total of 43 HIV patients with clinical conditions compatible with PML were obtained; 5 cases were confirmed by JCV testing. The main clinical finding was mental confusion. Median CD4 count was 54 cells/mm³.
CONCLUSIONS: Three of the five confirmed PML cases died; the time between diagnosis and death was 2, 5, and 6 months. It is important to consider JCV infection as a differential diagnosis.