[Initial ophthalmic manifestation of a fatal underlying disease : Importance of perimetry in unspecific visual deterioration].

A 55-year-old male patient presented with bilateral blurred vision. Chronic lymphocytic leukemia was generally known in the medical history, which was treated by immunochemotherapy with fludarabine, cyclophosphamide and rituximab. Static perimetry revealed a homonymous hemianopia to the left. The neurological examination was otherwise unremarkable. Progressive multifocal leukoencephalopathy (PML) was diagnosed by cranial magnetic resonance imaging and detection of JC virus DNA in the cerebrospinal fluid. The PML is a rare demyelinating disease of the central nervous system caused by reactivation of the JC virus. It affects patients with HIV, malignant hematological diseases and immunomodulatory therapy. A specific, antiviral treatment does not yet exist. The prognosis of PML is therefore poor. After a progressive course of the disease the patient died 4 months after the diagnosis.