Association between the inflammatory potential of diet and chronic renal failure: A cohort study of 163 433 UK Biobank participants.

OBJECTIVES

There is some preclinical evidence suggesting a pro-inflammatory diet reduces kidney function. In the present study, we aimed to investigate the association of inflammatory potential of diet with the risk of chronic renal failure (CRF).

METHODS

Cox regression models were used to examine the association between the energy-adjusted dietary inflammation index (E-DII) quartiles and CRF adjusting varying degrees of confounders. Restricted cubic spline regression was additionally adopted to determine the association of the continuous E-DII and CRF risk. A series of sensitivity and subgroup analyses were also conducted.

RESULTS

A total of 163,433 participants entered the primary analysis. During a mean follow-up period of 12.65 years, incident CRF occurred in 5, 333 participants (3.26%). The E-DII scores was stratified into four quartile groups. In a fully adjusted multivariable model, the adjusted hazard ratio for the second, third, and highest quartiles of E-DII intake was 1.12 (95% confidence interval [CI]: 1.04-1.21), 1.21 (95% CI: 1.12-1.31), and 1.23 (95% CI: 1.14-1.33), respectively, compared with the lowest quartile. Trend test indicated a statistically significant increasing trend with increasing E-DII quartiles (P < 0.0001). Similarly, restricted cubic spline regression displayed a positive association of continuous E-DII with CRF, wherein higher scores were linked to an elevated risk of CRF. Results of sensitivity analyses demonstrated consistent findings.

CONCLUSIONS

Diet with higher proinflammatory potential was linked to an increased risk of CRF. Implementing measures to limit the intake of pro-inflammatory foods or promoting the adoption of an anti-inflammatory dietary pattern could potentially reduce the occurrence of CRF.