Obesity (Silver Spring, Md.) · 2026
Bone Health After Metabolic and Bariatric Surgery: Osteometabolism Biomarkers, Bone Mineral Density, and Microarchitecture.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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de Almeida Camila Medeiros, Lopes Karynne Grutter, da Costa Tavares Bezerra Michelle, Leal Paulo Roberto Falcão, Bouskela Eliete, da Gama Eduardo Medeiros Ferreira, de Farias Maria Lucia Fleiuss, Madeira Miguel, Kraemer-Aguiar Luiz Guilherme
Аннотация
OBJECTIVE: The effects of metabolic and bariatric surgery on bone health still require further investigation. Osteometabolism biomarkers, bone microarchitecture (BM), and mineral density (BMD) of patients who have undergone Roux-en-Y gastric bypass (RYGB) within 2-5 years from surgery were compared to non-surgical age-, sex-, and BMI-matched controls.
METHODS: This cross-sectional study included 39 patients following RYGB (BG: aged = 39 ± 5 years, BMI = 42.2 ± 3.8 kg/m2) and 21 controls (CG). Circulating levels of albumin, calcium, phosphorus, magnesium, 25(OH) vitamin D, parathyroid hormone (PTH), carboxy-terminal telopeptide of type 1 collagen (CTX-1), and amino-terminal propeptide of type 1 procollagen (P1NP) were assayed. BMD and BM were assessed by dual-energy X-ray absorptiometry (DXA) and three-dimensional high-resolution peripheral quantitative computed tomography system (HR-pQCT).
RESULTS: BG presented with higher circulating phosphorus, PTH, CTX-1, and P1NP and lower 25(OH) vitamin D compared to CG. DXA parameters did not differ between groups. However, HR-pQCT revealed significant derangements in BM (trabecular thickness, cortical bone density, and outer trabecular volumetric BMD) in BG. BG showed tibia-specific trabecular microarchitecture impairment, while sex and BMI showed the expected associations with BM measures.
CONCLUSIONS: RYGB was associated with detrimental effects on osteometabolism biomarkers, as well as on density and structural parameters of BM. Early preventive strategies aimed at mitigating these deleterious effects should be systematically evaluated to minimize their long-term impact.
TRIAL REGISTRATION: ClinicalTrials.gov (NCT04193397).
METHODS: This cross-sectional study included 39 patients following RYGB (BG: aged = 39 ± 5 years, BMI = 42.2 ± 3.8 kg/m2) and 21 controls (CG). Circulating levels of albumin, calcium, phosphorus, magnesium, 25(OH) vitamin D, parathyroid hormone (PTH), carboxy-terminal telopeptide of type 1 collagen (CTX-1), and amino-terminal propeptide of type 1 procollagen (P1NP) were assayed. BMD and BM were assessed by dual-energy X-ray absorptiometry (DXA) and three-dimensional high-resolution peripheral quantitative computed tomography system (HR-pQCT).
RESULTS: BG presented with higher circulating phosphorus, PTH, CTX-1, and P1NP and lower 25(OH) vitamin D compared to CG. DXA parameters did not differ between groups. However, HR-pQCT revealed significant derangements in BM (trabecular thickness, cortical bone density, and outer trabecular volumetric BMD) in BG. BG showed tibia-specific trabecular microarchitecture impairment, while sex and BMI showed the expected associations with BM measures.
CONCLUSIONS: RYGB was associated with detrimental effects on osteometabolism biomarkers, as well as on density and structural parameters of BM. Early preventive strategies aimed at mitigating these deleterious effects should be systematically evaluated to minimize their long-term impact.
TRIAL REGISTRATION: ClinicalTrials.gov (NCT04193397).