Global prevalence of anxiety, depression and stress in women with breast cancer: A systematic review and meta-analysis.

BACKGROUND

A consistent correlation has been highlighted between screening-based mental health indicators and women suffering from breast cancer (BC), which significantly reduced their related quality of life perceptions. This systematic review and meta-analysis aimed to comprehensively evaluate the prevalence rates of Anxiety, Depression and Stress in women with BC over the last decade.

METHODS

This systematic review was conducted in accordance with Cochrane Collaboration guidelines and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) statement. It included studies published between January 2015 and March 2025, focusing on women with BC who experienced anxiety, depression and stress. A comprehensive literature search was conducted across multiple databases, including PubMed, Clinical Key, Scopus, Embase, CINAHL, and Web of Science. Data extraction and risk of bias assessment were independently performed by two reviewers experienced in conducting systematic reviews. Meta-analyses were conducted using random-effects models, and statistical heterogeneity was evaluated using the I2 statistic.

RESULTS

Sixty studies met the inclusion criteria, representing diverse populations across various countries. The Sample sizes ranged from 30 to 16,392 participants, with women aged 18-82 years. A meta-analysis indicated that women with breast cancer had a 37.3% increased risk of developing anxiety compared to those without breast cancer. Similarly, depression and stress experienced 36% and 38.2% respectively.

CONCLUSION

There is a strong link between women with breast cancer and their traumatic or adverse life experiences. Anxiety, depression, and stress are common mental health indicators that can affect the outcome of cancer. However, several strategies can help lower future consequences. Stakeholders, policymakers, and healthcare professionals can enhance clinical practices, update care guidelines, and implement evidence-based strategies to improve women's mental health and overall well-being.