Clinical clues to AIDS. Recognizing the dermatologic and nondermatologic manifestations.

As more types of human immunodeficiency virus (HIV) are recognized and as the incidence of acquired immunodeficiency syndrome (AIDS) increases, more and more manifestations of HIV infection will be recognized. Dermatologic conditions often provide a means of making the presumptive diagnosis. Months or years of asymptomatic disease may have elapsed before cutaneous symptoms appear. However, care must be taken not to over-diagnose on the basis of a single nonspecific finding. To say that all patients with psoriasis have AIDS, for example, would be absurd. Yet an explosive flare of psoriasis or an atypical new presentation should alert the clinician to the possibility of HIV infection. Certainly, multiple suggestive dermatologic findings in any patient would essentially confirm the diagnosis of AIDS regardless of the status of antibody reactivity. A wide range of nondermatologic physical findings can also signal HIV infection. None are specific for AIDS, but again, findings that are rare, atypical, or severe in a normal host should be viewed with suspicion, and any of the signs in an at-risk patient should prompt the clinician to consider AIDS and to include specific tests in the workup. By becoming familiar with the many faces of HIV infection, the clinician can recognize its varied manifestations that may suggest the diagnosis in the absence of other findings.