Phytochemistry · 2025
Terpene and lignan glycosides from the leaves of Cyclocarya paliurus and their anti-inflammatory activity.
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Fang Si-Yang, Liu Jia, Wu Chang-Jian, Zhang Xing-Gui, Dong Hui-Lin, Zhang Dong-Jian, Hu Can, Zhang Jian, Pan Ke, Yin Zhi-Qi, Qin Yan-Hua, Wang Lei
Аннотация
Nine undescribed glycosides including five terpene glycosides (1-5) and four lignan glycosides (6-9), together with thirteen known compounds, were isolated from the n-BuOH fraction of the leaves of Cyclocarya paliurus. Their structures including absolute configuration were elucidated by extensive spectroscopic analysis and computational methods including NMR and ECD calculations. All isolates were screened for inhibitory effect against LPS-induced nitric oxide production in RAW 264.7 cells. Compound 12 showed the most potent activity with an IC50 value of 12.55 μM, comparable to that of the positive control dexamethasone (9.27 μM).