Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats.
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Moreira Veridiana Mota, Almeida Douglas, da Silva Franco Claudinéia Conationi, Gomes Rodrigo Mello, Palma-Rigo Kesia, Prates Kelly Valério, Tófolo Laize Peron, Malta Ananda, Francisco Flávio Andrade, Pavanello Audrei, Previate Carina, da Silva Silveira Sandra, Ribeiro Tatiane Aparecida, Martins Isabela Peixoto, de Moraes Ana Maria Praxedes, Matiusso Camila Cristina Ianoni, Saavedra Lucas Paulo Jacinto, de Barros Machado Katia Gama, Fabbri Corá Thauany, Gongora Adriane, Cardozo Lucas Eduardo, da Silva Paulo Henrique Olivieri, Venci Renan, Vieira Elaine, de Oliveira Júlio Cezar, Miranda Rosiane Aparecida, de Souza Helenir Medri, Miksza Daniele, da Costa Lima Luiz Delmar, de Castro-Prado Marialba Avezum Alves, Rinaldi Wilson, de Freitas Mathias Paulo Cezar
Аннотация
ABSTRACT: We tested the hypothesis that moderate exercise training, performed early, starting during adolescence or later in life during adulthood, can inhibit tumour cell growth as a result of changes in biometric and metabolic markers. Male rats that were 30 and 70 days old performed a treadmill running protocol over 8 weeks for 3 days week-1 , 44 min day-1 and at 55-65% V̇O2max . After the end of training, a batch of rats was inoculated with Walker 256 carcinoma cells. At 15 days after carcinoma cell inoculation, the tumour was weighed and certain metabolic parameters were evaluated. The data demonstrated that physical performance was better in rats that started exercise training during adolescence according to the final workload and V̇O2max . Early or later moderate exercise training decreased the cachexia index, cell proliferation and tumour growth; however, the effects were more pronounced in rats that exercised during adolescence. Low glycaemia, insulinaemia and tissue insulin sensitivity was not reverted in Walker 256 tumour-bearing rats who trained during adolescence. Cancer growth can be attenuated by the beneficial programming effect of moderate exercise training, especially if it begins during adolescence. In addition, improvement in glucose-insulin homeostasis might be involved in this process.