Regioselective Allylic Aminoalkylation Enabled by Dual Chromium/Photoredox Catalysis.

A highly branch-regioselective allylic aminoalkylation reaction has been developed through dual chromium/photoredox catalysis, providing an economical and sustainable alternative to conventional methods that rely on noble transition metals, such as palladium. This transformation proceeds under mild conditions and enables the radical coupling of readily accessible allylic bromides with α-silylamines, yielding a diverse range of synthetically valuable branched homoallylic amines. Notably, the method features a broad substrate scope and excellent functional group tolerance, accommodating various aromatic and aliphatic allylic bromides as well as diverse N-heterocyclic amines.