Multifocal melanoma of the conjunctiva in an African American patient with neurofibromatosis type 1.

A 22-year-old African American female with neurofibromatosis type 1 and multifocal conjunctival melanoma with scleral invasion. The lesion was detected during pregnancy, and after early induction of childbirth, staging by sentinel lymph node biopsy and imaging studies were performed. Systemic evaluation was negative, and the patient was treated with excisional biopsy and cryotherapy. The recurrent multifocal melanoma with scleral extension was treated with brachytherapy by a 2-stage procedure. Follow-up at 2 years reveals the absence of recurrence and 20/25 visual acuity.