MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1590/0004-282x20130121

Медицинская библиотека · Arquivos de neuro-psiquiatria · 2013

Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive.

Fragoso Yara Dadalti, Mendes Maria Fernanda, Arruda Walter Oleschko, Becker Jefferson, Brooks Joseph Bruno Bidin, Carvalho Margarete de Jesus, Comini-Frota Elizabeth Regina, Domingues Renan Barros, Ferreira Maria Lucia Brito, Finkelsztejn Alessandro, Gama Paulo Diniz da, Gomes Sidney, Gonçalves Marcus Vinicius Magno, Kaimen-Maciel Damacio Ramon, Morales Rogério de Rizo, Muniz Andre, Ruocco Heloisa Helena, Salgado Pedro Rippel, Albuquerque Livia Brito Bezerra de, Gama Rodrigo Assad Diniz da, Georgeto Sergio, Lopes Josiane, Oliveira Celso Luis Silva, Oliveira Francisco Tomaz Meneses, Safanelli Juliana, Saldanha Patricia Correia de Oliveira, Satomi Massaco

СтатьяПеревод в очереди

Аннотация

OBJECTIVE

Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection. The objective of the present study was to assess the prevalence of JCV-DNA in Brazilian patients using natalizumab.

METHOD: Qualitative detection of the JCV in the serum was performed with real-time polymerase chain reaction (PCR).

RESULTS

In a group of 168 patients with MS who were undergoing treatment with natalizumab, JCV-DNA was detectable in 86 (51.2%) patients.

DISCUSSION: Data on JCV-DNA in Brazil add to the worldwide assessment of the prevalence of the JCV in MS patients requiring treatment with natalizumab.

Для цитирования: Fragoso Yara Dadalti, Mendes Maria Fernanda, Arruda Walter Oleschko, Becker Jefferson, Brooks Joseph Bruno Bidin, Carvalho Margarete de Jesus, Comini-Frota Elizabeth Regina, Domingues Renan Barros, Ferreira Maria Lucia Brito, Finkelsztejn Alessandro, Gama Paulo Diniz da, Gomes Sidney, Gonçalves Marcus Vinicius Magno, Kaimen-Maciel Damacio Ramon, Morales Rogério de Rizo, Muniz Andre, Ruocco Heloisa Helena, Salgado Pedro Rippel, Albuquerque Livia Brito Bezerra de, Gama Rodrigo Assad Diniz da, Georgeto Sergio, Lopes Josiane, Oliveira Celso Luis Silva, Oliveira Francisco Tomaz Meneses, Safanelli Juliana, Saldanha Patricia Correia de Oliveira, Satomi Massaco. Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive.. Arquivos de neuro-psiquiatria. 2013. DOI: 10.1590/0004-282x20130121.

Предметные рубрики MeSH

AdultAntibodies, Monoclonal, HumanizedBrazilDNA, ViralFemaleHumansJC VirusLeukoencephalopathy, Progressive MultifocalMaleMiddle AgedMultiple SclerosisNatalizumabReal-Time Polymerase Chain ReactionRisk Factors
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.