The American journal of clinical nutrition · 2004
Conjugated linoleic acid reduces parathyroid hormone in health and in polycystic kidney disease in rats.
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Weiler Hope, Austin Susan, Fitzpatrick-Wong Shirley, Nitschmann Evan, Bankovic-Calic Neda, Mollard Rebecca, Aukema Harold, Ogborn Malcolm
Аннотация
BACKGROUND: Feeding conjugated linoleic acid (CLA) is reported to reduce prostaglandin E(2) synthesis, which is required for parathyroid hormone (PTH) release.
OBJECTIVE: This study was undertaken to determine whether CLA would suppress hyperparathyroidism and the resulting high-turnover bone disease in a rat model of polycystic kidney disease (PKD).
DESIGN: Outcome measurements were conducted after 8 wk of feeding diets supplemented with and without CLA (1% of dietary fat) to Han:SPRD-cy male rats (n = 52). PTH, bone formation, and resorption were assessed in addition to femur bone mass with use of dual-energy X-ray absorptiometry.
RESULTS: CLA feeding resulted in attenuation of PTH concentrations in both PKD-affected and nonaffected rats (by 60%) but did not significantly alter bone formation and resorption.
CONCLUSION: Reduction in PTH may open possibilities for CLA as an adjunctive therapy in secondary hyperparathyroidism.
OBJECTIVE: This study was undertaken to determine whether CLA would suppress hyperparathyroidism and the resulting high-turnover bone disease in a rat model of polycystic kidney disease (PKD).
DESIGN: Outcome measurements were conducted after 8 wk of feeding diets supplemented with and without CLA (1% of dietary fat) to Han:SPRD-cy male rats (n = 52). PTH, bone formation, and resorption were assessed in addition to femur bone mass with use of dual-energy X-ray absorptiometry.
RESULTS: CLA feeding resulted in attenuation of PTH concentrations in both PKD-affected and nonaffected rats (by 60%) but did not significantly alter bone formation and resorption.
CONCLUSION: Reduction in PTH may open possibilities for CLA as an adjunctive therapy in secondary hyperparathyroidism.