[Aldosterone exacerbates chronic renal insufficiency].

UNLABELLED: It is now clear that the synthesis of aldosterone (A) and the expression of the mineralocorticoid receptor also appear in the extra-adrenal tissues. Experimental studies have succeeded in showing the connection between A and the pathological mechanisms that appear in the development of chronic kidney diseases (CKD). Unfortunately, it is not currently possible to decide whether the effects of A are clinically relevant or not due to the lack of controlled trials.

CONCLUSION

A very likely has a role in the development of CKD, although considerably more clinical investigation is needed.