Fertility and sterility · 2010
Changes of CD4+CD25high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients.
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Mei Shanshan, Tan Jianping, Chen Hui, Chen Ying, Zhang Jianping
Аннотация
OBJECTIVE: To investigate the proportions of CD4+CD25high T cells and forkhead box p3 (FOXP3) expression in peripheral blood and decidua in patients with unexplained recurrent spontaneous abortion (URSA).
DESIGN: Prospective clinical study.
SETTING: University hospital.
PATIENT(S): 125 URSA patients, 35 normal early pregnant women, and 28 normal nonpregnant women.
INTERVENTION(S): Measurements of CD4+CD25high T cells and FOXP3 expression in peripheral blood and decidua.
MAIN OUTCOME MEASURE(S): The proportions of CD4+CD25high T cells and FOXP3 expression.
RESULT(S): In peripheral blood, statistically significantly higher proportions of CD4+CD25high T cells and FOXP3 expression were observed in normal early pregnant women compared with normal nonpregnant women and URSA patients; a statistically significantly lower proportion of CD4+CD25high T cells was observed in nonpregnant URSA patients compared with URSA patients who had early miscarriages and normal nonpregnant women. In the decidua, statistically significantly lower proportions of CD4+CD25high T cells and FOXP3 expression were found in URSA patients with early miscarriages compared with normal early pregnant women.
CONCLUSION(S): The CD4+CD25high T cells may play an important role in maintaining a normal pregnancy. The reduction in CD4+CD25high T cells may involve in the pathogenesis of URSA, and is correlated with lower FOXP3 expression.
DESIGN: Prospective clinical study.
SETTING: University hospital.
PATIENT(S): 125 URSA patients, 35 normal early pregnant women, and 28 normal nonpregnant women.
INTERVENTION(S): Measurements of CD4+CD25high T cells and FOXP3 expression in peripheral blood and decidua.
MAIN OUTCOME MEASURE(S): The proportions of CD4+CD25high T cells and FOXP3 expression.
RESULT(S): In peripheral blood, statistically significantly higher proportions of CD4+CD25high T cells and FOXP3 expression were observed in normal early pregnant women compared with normal nonpregnant women and URSA patients; a statistically significantly lower proportion of CD4+CD25high T cells was observed in nonpregnant URSA patients compared with URSA patients who had early miscarriages and normal nonpregnant women. In the decidua, statistically significantly lower proportions of CD4+CD25high T cells and FOXP3 expression were found in URSA patients with early miscarriages compared with normal early pregnant women.
CONCLUSION(S): The CD4+CD25high T cells may play an important role in maintaining a normal pregnancy. The reduction in CD4+CD25high T cells may involve in the pathogenesis of URSA, and is correlated with lower FOXP3 expression.