Natural product research · 2025
Two new compounds from the roots of Paeonia lactiflora Pall. and their anti-inflammatory effects.
СтатьяНазвание и аннотация: Перевод в очереди
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Fu Bo, Zhang Jin-Ling, Wu Jia-Tong, Wang Si-Yi, Zhang Yi-Qiang, Pan Juan, Guan Wei, Hao Zhi-Chao, Kuang Hai-Xue, Chen Qing-Shan, Zhang Li-Li, Yang Bing-You, Liu Yan
Аннотация
Two new compounds (1-2), together with six known ones (3-8), were isolated from the roots of Paeonia lactiflora Pall. The structures of two new compounds were elucidated based on HR-ESI-MS, UV, and NMR spectroscopic data analysis. Moreover, the anti-inflammatory activities of compounds 1-8 were determined using LPS-induced RAW 264.7 cells. Compounds 2, 6, and 8 showed the most potent inhibitory activities on NO production with IC50 values of 17.34 ± 1.5, 27.22 ± 1.3, and 14.79 ± 1.7 μM, respectively. Compounds 4 and 7 showed moderate inhibitory activities. Compounds 3 and 5 showed relatively weak inhibitory activities.