Wei sheng yan jiu = Journal of hygiene research · 2013
[Effects of CdTe QDs on chromosome aberration of CHL cells in vitro].
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Xie Guangyun, Wang Quankai, Wang Anna, Wang Jian, Liu Li, Huang Peili, Sun Zhiwei
Аннотация
OBJECTIVE: To observed the chromosome oberration of CHL cells induced by CdTe QDs.
METHODS: The chromosome oberration test of Chinese hamster lung (CHL) cell was conducted in CdTe QDs at the concentrations of 1.6, 3.2, 6.3, 12.6 and 25.2 microl/ml, under the metabolic (+S9) and non-metabolic (-S9) activation systems.
RESULTS: The chromosome oberration rate of 12.6 and 25.2 microl/ml CdTe QDs groups were significantly higher than the control groups (P<0.01) Under the condition of metabolic activation. Main types of chromosomal aberrations was broken, fragmented and exchange.
CONCLUSION: It was suggested that CdTe QDs could induce the effects of chromosome oberration under the metabolic activation systems (+S9).
METHODS: The chromosome oberration test of Chinese hamster lung (CHL) cell was conducted in CdTe QDs at the concentrations of 1.6, 3.2, 6.3, 12.6 and 25.2 microl/ml, under the metabolic (+S9) and non-metabolic (-S9) activation systems.
RESULTS: The chromosome oberration rate of 12.6 and 25.2 microl/ml CdTe QDs groups were significantly higher than the control groups (P<0.01) Under the condition of metabolic activation. Main types of chromosomal aberrations was broken, fragmented and exchange.
CONCLUSION: It was suggested that CdTe QDs could induce the effects of chromosome oberration under the metabolic activation systems (+S9).