European journal of case reports in internal medicine · 2017
Delayed Leukoencephalopathy: Three Case Reports and a Literature Review.
СтатьяНазвание и аннотация: Перевод в очереди
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Torralba-Morón Ángel, Ortiz-Imedio Juan, Morales-Conejo Montserrat, Ruiz-Morales Juan, Guerra-Vales Juan-Manuel
Аннотация
BACKGROUND: Delayed leukoencephalopathy (DL) is a rare entity associated with cerebral hypoxia and heroin consumption. We describe the clinical course of three cases of DL due to non-heroin drug use.
MATERIAL AND METHODS: We describe the cases of three DL patients admitted to our hospital in 2012.
DISCUSSION: These cases contribute to the aetiological spectrum of DL since multifactorial causes could account for the clinical symptoms.
LEARNING POINTS: Substances toxic to the CNS can damage the CNS directly (direct toxicity) or by depressing the respiratory centre (cerebral hypoxia).As clinical manifestations can appear after a time lag, we recommend a period of initial monitoring.Histological and radiological findings can contribute to better understanding of the pathophysiological mechanisms and causes involved.
MATERIAL AND METHODS: We describe the cases of three DL patients admitted to our hospital in 2012.
DISCUSSION: These cases contribute to the aetiological spectrum of DL since multifactorial causes could account for the clinical symptoms.
LEARNING POINTS: Substances toxic to the CNS can damage the CNS directly (direct toxicity) or by depressing the respiratory centre (cerebral hypoxia).As clinical manifestations can appear after a time lag, we recommend a period of initial monitoring.Histological and radiological findings can contribute to better understanding of the pathophysiological mechanisms and causes involved.