The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2016
Application of spectroscopy (1HMRS) to assess liver metabolite concentrations in rats with intrauterine growth restriction.
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Wang Tao, Chen Pingyang, Bian Dujun, Chen Juncao
Аннотация
OBJECTIVE: Proton magnetic resonance spectroscopy (1H-MRS) measurement of liver metabolism in intrauterine growth restriction rats has seldom been reported. This study investigated the application of 1H-MRS in assessing liver metabolism in newborn pups that experienced intrauterine growth restriction.
METHODS: Intra-uterine growth restriction was established by feeding rats low-protein diets during pregnancy. Newborn pups received conventional magnetic resonance imaging and 1H-MRS using a 3.0T whole body MR scanner at 3, 8 and 12 weeks post birth.
RESULTS: The success rate of 1H-MRS was 83.33%. Significantly lower body weight, BMI and body length at 3 weeks as well as significantly lower body weight, BMI and waist circumference at 8 and 12 weeks were observed in newborn pups of IUGR rats compared with pups of control rats. Significant differences in ACho/H2O, ACr/H2O, AGlx/H2O and ALipid/H2O at 3 and 8 weeks as well as significant differences in ACr/H2O, ALipid/H2O and AGlx/H2O at 12 weeks were observed between pups of control rats and pups of IUGR rats.
CONCLUSION: 1H-MRS allows noninvasive assessment of liver metabolism in the rat and demonstrated the poor liver development of rats that experienced IUGR.
METHODS: Intra-uterine growth restriction was established by feeding rats low-protein diets during pregnancy. Newborn pups received conventional magnetic resonance imaging and 1H-MRS using a 3.0T whole body MR scanner at 3, 8 and 12 weeks post birth.
RESULTS: The success rate of 1H-MRS was 83.33%. Significantly lower body weight, BMI and body length at 3 weeks as well as significantly lower body weight, BMI and waist circumference at 8 and 12 weeks were observed in newborn pups of IUGR rats compared with pups of control rats. Significant differences in ACho/H2O, ACr/H2O, AGlx/H2O and ALipid/H2O at 3 and 8 weeks as well as significant differences in ACr/H2O, ALipid/H2O and AGlx/H2O at 12 weeks were observed between pups of control rats and pups of IUGR rats.
CONCLUSION: 1H-MRS allows noninvasive assessment of liver metabolism in the rat and demonstrated the poor liver development of rats that experienced IUGR.