Discordant Duane's retraction syndrome in monozygotic twins.

PURPOSE: To evaluate whether differences in the intrauterine environment caused discordant Duane's retraction syndrome in monozygotic twins.

METHODS

Pathology records were reviewed to determine monozygosity.

RESULTS

Discordant Duane's retraction syndrome was present in twin boys with identical genetic foundations who had different intrauterine environments. The placenta indicated areas of anastomosis between the two umbilical cords suggestive of twin-to-twin transfusion that resulted in a visible growth discordance.

CONCLUSIONS

Intrauterine environment influences ocular development, and twin-to-twin transfusion may cause Duane's retraction syndrome.