Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Li Shumei, Daamen Marcel, Scheef Lukas, Gaertner Florian C, Buchert Ralph, Buchmann Martina, Buerger Katharina, Catak Cihan, Dobisch Laura, Drzezga Alexander, Ertl-Wagner Birgit, Essler Markus, Fliessbach Klaus, Haynes John Dylan, Incesoy Enise Irem, Kilimann Ingo, Krause Bernd J, Lange Catharina, Laske Christoph, Priller Josef, Ramirez Alfredo, Reimold Matthias, Rominger Axel, Roy Nina, Scheffler Klaus, Maurer Angelika, Schneider Anja, Spottke Annika, Spruth Eike Jakob, Teipel Stefan J, Tscheuschler Maike, Wagner Michael, Wolfsgruber Steffen, Düzel Emrah, Jessen Frank, Peters Oliver, Boecker Henning, DELCODE Study Group
Аннотация
OBJECTIVE: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus.
METHODS: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDAβ+) and amyloidnegative SCD (SCDβ-) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVR=⫖FBB).
RESULTS: ReHo was significantly higher (voxel-wise p < 0.01, cluster-level p < 0.05) in the bilateral precuneus for SCDAβ+patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDAβ+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDAβ+) and precuneus SUVRFBB (both groups).
CONCLUSION: While partial confounding influences due to a higher APOE ε4 carrier ratio among SCDAβ+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-β load, highlighting incipient pathology in stage 2 of the AD continuum.