Disseminated intravascular coagulation in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Chen Chun-Bing, Hsu Tsun-Hao, Chung-Yee Hui Rosaline, Lu Chun-Wei, Chen Wei-Ti, Chiang Pin-Hsuan, Wang Chuang-Wei, Chuang Shiow-Shuh, Yang Jui-Yung, Yang Shih-Yi, Chang Shu-Ying, Hsiao Yen-Chang, Kao Kuo-Chin, Hu Han-Chung, Wu Ting-Shu, Hsu Chao-Wei, Hui-Kang Ma David, Chen Shin-Yi, Tian Ya-Chung, Cheng Chi-Yuan, Chen Chi-Hua, Chi Min-Hui, Wu Ming-Ying, Liu Ren-Feng, Wang Chi-Hui, Chang Ya-Ching, Lin Jing-Yi, Ho Hsin-Chun, Yu-Wei Lin Yang, Chang Chee Jen, Lin Yu-Jr, Ku Cheng-Lung, Hung Shuen-Iu, Chung Wen-Hung, Taiwan Severe Cutaneous Adverse Reaction Consortium
Аннотация
OBJECTIVE: This study aimed to investigate the risk and outcomes of disseminated intravascular coagulation in patients with SJS/TEN.
METHODS: We analyzed the disseminated intravascular coagulation profiles of patients receiving a diagnosis of SJS/TEN between 2010 and 2019.
RESULTS: We analyzed 150 patients with SJS/TEN (75 with SJS, 22 with overlapping SJS/TEN, and 53 with TEN) and their complete disseminated intravascular coagulation profiles. Disseminated intravascular coagulation was diagnosed in 32 patients (21.3%), primarily those with TEN. It was significantly associated with systemic complications, including gastrointestinal bleeding, respiratory failure, renal failure, liver failure, infection, and bacteremia. Additionally, SJS/TEN patients with disseminated intravascular coagulation had elevated procalcitonin levels. Among patients with SJS/TEN, disseminated intravascular coagulation was associated with a greater than 10-fold increase in mortality (78.1% vs 7%).
LIMITATIONS: The study limitations include small sample size and a single hospital system.
CONCLUSION: Disseminated intravascular coagulation is a potential complication of SJS/TEN and associated with higher mortality. Early recognition and appropriate management of this critical complication are important for patients with SJS/TEN.