Emergency medicine Australasia : EMA · 2025
Blood culture collection and administration of intravenous ceftriaxone by paramedics in patients with suspected sepsis (the pass trial).
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cudini Daniel, Smith Karen, Shao Jeffery, Bernard Stephen, Okyere Daniel, Nehme Ziad, Nehme Emily, Anderson David, Magnuson Nicole, Thursky Karin, Mori Dhruv, Oosthuizen De Witt, Udy Andrew
Аннотация
OBJECTIVE: To evaluate the feasibility of pre-hospital blood culture (BC) collection and intravenous (IV) antibiotic administration in patients with suspected sepsis.
METHODS: In this open-label trial, BCs were collected in all participants, who were then randomised to ongoing care (control) or ongoing care plus 2 g IV ceftriaxone (intervention). Time to antibiotic administration was the primary outcome.
RESULTS: Thirty-five patients were enrolled and randomised (21 control, 14 intervention). BCs were obtained in 89% (n = 31/35) and grew a pathogen in 42% (n = 13/31). Intervention patients received antibiotics a median of 108 (95% CI 34 to 170) minutes earlier (P < 0.01).
CONCLUSION: BCs were successfully obtained by paramedics, and pre-hospital IV ceftriaxone resulted in expedited antibiotic administration.
CLINICAL TRIAL REGISTRATION: ACTRN12618000199213.
METHODS: In this open-label trial, BCs were collected in all participants, who were then randomised to ongoing care (control) or ongoing care plus 2 g IV ceftriaxone (intervention). Time to antibiotic administration was the primary outcome.
RESULTS: Thirty-five patients were enrolled and randomised (21 control, 14 intervention). BCs were obtained in 89% (n = 31/35) and grew a pathogen in 42% (n = 13/31). Intervention patients received antibiotics a median of 108 (95% CI 34 to 170) minutes earlier (P < 0.01).
CONCLUSION: BCs were successfully obtained by paramedics, and pre-hospital IV ceftriaxone resulted in expedited antibiotic administration.
CLINICAL TRIAL REGISTRATION: ACTRN12618000199213.