Fertility and sterility · 2011
Birth of a healthy infant after intracytoplasmic sperm injection using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.
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Hattori Hiromitsu, Nakajo Yukiko, Ito Chizuru, Toyama Yoshiro, Toshimori Kiyotaka, Kyono Koichi
Аннотация
OBJECTIVE: To describe the delivery of a healthy female infant after intracytoplasmic sperm injection (ICSI) using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.
DESIGN: Case report.
SETTING: Private assisted reproductive technology clinic in Japan.
PATIENT(S): A couple with male factor infertility due to Kartagener's syndrome.
INTERVENTION(S): Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline.
MAIN OUTCOME MEASURE(S): Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI.
RESULT(S): The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered.
CONCLUSION(S): With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome.
DESIGN: Case report.
SETTING: Private assisted reproductive technology clinic in Japan.
PATIENT(S): A couple with male factor infertility due to Kartagener's syndrome.
INTERVENTION(S): Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline.
MAIN OUTCOME MEASURE(S): Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI.
RESULT(S): The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered.
CONCLUSION(S): With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome.