Birth of a healthy infant after intracytoplasmic sperm injection using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.

OBJECTIVE

To describe the delivery of a healthy female infant after intracytoplasmic sperm injection (ICSI) using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.

DESIGN

Case report.

SETTING

Private assisted reproductive technology clinic in Japan.

PATIENT(S): A couple with male factor infertility due to Kartagener's syndrome.

INTERVENTION(S): Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline.

MAIN OUTCOME MEASURE(S): Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI.

RESULT(S): The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered.

CONCLUSION(S): With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome.