Cardiology journal · 2010
Prognostic value of cardiac troponin T elevation is independent of renal function and clinical findings in heart failure patients.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Orea-Tejeda Arturo, Sánchez-González Luis R, Castillo-Martínez Lilia, Valdespino-Trejo Adrian, Sánchez-Santillán Rocío N, Keirns-Davies Candace, Colín-Ramírez Eloisa, Montańo-Hernández Patricia, Dorantes-García Joel
Аннотация
BACKGROUND: The aim of this study is to determine the prevalence and prognostic value of elevated cardiac troponin (cTnT) and its association with clinical characteristics according to renal function status in patients with stable heart failure.
METHODS: In a prospective observational study, 152 consecutive patients from the Heart Failure Clinic of the INCMNSZ were followed for a period of 42 months. All underwent clinical evaluation, echocardiography, and determination of body composition by electric bioimpedance to identify hypervolemia. Concentrations of cTnT were quantified by immunoassay with electrochemoluminescence and > or = 0.02 ng/mL levels were considered elevated. Also glomerular filtration rate (eGFR) was estimated using the Cockcroft-Gault equation.
RESULTS: Elevated cTnT was significantly associated with increased all-cause mortality in the observational period even after adjusting for eGFR < 60 mL/min/1.73 m2 and clinical findings such as hypertension, functional class, loop diuretics, angiotensin converting enzyme inhibitors, pulmonary pressure and hypervolemia in Cox regression analysis with a hazard ratio of 4.58 (95% confidence interval: 1.84-11.45).
CONCLUSIONS: Heart failure patients with elevated cardiac-specific troponin T are at increased risk of death independently of the presence of chronic kidney disease.
METHODS: In a prospective observational study, 152 consecutive patients from the Heart Failure Clinic of the INCMNSZ were followed for a period of 42 months. All underwent clinical evaluation, echocardiography, and determination of body composition by electric bioimpedance to identify hypervolemia. Concentrations of cTnT were quantified by immunoassay with electrochemoluminescence and > or = 0.02 ng/mL levels were considered elevated. Also glomerular filtration rate (eGFR) was estimated using the Cockcroft-Gault equation.
RESULTS: Elevated cTnT was significantly associated with increased all-cause mortality in the observational period even after adjusting for eGFR < 60 mL/min/1.73 m2 and clinical findings such as hypertension, functional class, loop diuretics, angiotensin converting enzyme inhibitors, pulmonary pressure and hypervolemia in Cox regression analysis with a hazard ratio of 4.58 (95% confidence interval: 1.84-11.45).
CONCLUSIONS: Heart failure patients with elevated cardiac-specific troponin T are at increased risk of death independently of the presence of chronic kidney disease.
Предметные рубрики MeSH
AgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsBlood VolumeElectrochemical TechniquesFemaleGlomerular Filtration RateHeart FailureHumansHypertensionImmunoassayKidneyLuminescent MeasurementsLungMaleMiddle AgedMyocardiumPredictive Value of TestsPressurePrognosisProportional Hazards ModelsProspective StudiesSodium Potassium Chloride Symporter InhibitorsTroponin T