Biotechnic & histochemistry : official publication of the Biological Stain Commission · 2022
Therapeutic effects of apocynin on ovarian ischemia-reperfusion induced lung injury.
СтатьяНазвание и аннотация: Перевод в очереди
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Tanyeli Ayhan, Guzel Erdogan Derya, Comakli Selim, Polat Elif, Guler Mustafa Can, Eraslan Ersen, Doganay Songul
Аннотация
Ovarian ischemia-reperfusion (I-R) injury may damage remote organs, including the lungs. We investigated whether apocynin, a NADPH oxidase inhibitor, might protect against ovarian I-R induced apoptosis in the lungs of rats. Bilateral ovarian I-R was induced for 3 h, then apocynin was applied at two concentrations. Lung tissue was evaluated using spectrophotometric and immunohistochemical methods. We found that I-R increased total oxidant status (TOS), oxidative stress index (OSI) and myeloperoxidase (MPO) levels, and immunostaining of nuclear factor kappa-B (NF-κB), light chain 3B (LC3B), interleukin 1-beta (IL-1β), caspase-3 and tumor necrosis factor-alpha (TNF-α), but decreased superoxide dismutase (SOD) values. Apocynin application to I-R injured rats enhanced recovery of lung tissue oxidants and improved both histology and frequency of apoptosis.