[Experimental myocardial infarction in atherosclerosis--various methods of pharmacological correction].

The effect of the beta-blocker propranolol and of bensonal, a barbituric acid derivative stimulating microsomal oxidation of the liver monooxygenase, was evaluated using the model of experimental myocardial infarction (EMI) in the presence of 3-month cholesterol atherosclerosis. Using light and electron microscopy, polarography and weight planimetry atherosclerosis was shown to complicate considerably the course of EMI analyzed 1, 3, 7, 15 and 30 days after the coronary artery ligation. The drugs given at the same intervals improved the structure and metabolism of different myocardial zones while limiting necrotic areas for 7 days of EMI.