A novel method for preparation of Eudragit RL microcapsules.

A novel technique for the preparation of Eudragit RL microcapsules is described. The technique is based on the principle of solvent evaporation. Diclofenac sodium is used as a model drug for encapsulation. A solution of drug and Eudragit RL dissolved in acetone-isopropyl alcohol (1:1) is sprayed in liquid paraffin. The microcapsules obtained were uniform and free flowing particles. The release rate was more sustained by increasing the polymer concentration. The experimental procedure promises a rapid and convenient method for the preparation of Eudragit RL-microcapsules.