Annals of hepatology · 2012
Protective role of standardized Feronia limonia stem bark methanolic extract against carbon tetrachloride induced hepatotoxicity.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Jain Mahendra, Kapadia Rakhee, Jadeja Ravirajsinh Navalsinh, Thounaojam Menaka Chanu, Devkar Ranjitsinh Vijaysinh, Mishra Shri Hari
Аннотация
OBJECTIVE: This study evaluates hepatoprotective potential of Feronia limonia stem bark (FSB) extracts and fractions using experimental models.
MATERIALS AND METHODS: Activity levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and cell viability were evaluated in HepG2 cells treated with carbon tetrachloride (CCl4) in presence or absence of FL extracts or fractions. Also, plasma markers of hepatic damage, hepatic antioxidants, lipid peroxidation and histopathological alterations were assessed in rats treated with CCl4 alone or in combination with 200 or 400 mg/kg bodyweight (BW) of FSB-7 or 25 mg/kg BW of silymarin.
RESULTS: In vitro co-supplementation of FSB extracts or fractions recorded varying degree of hepatoprotective potentials. Also, pre-supplementation of FSB methanolic extract (FSB-7) followed by CCl4 treatment significantly prevented hepatic damage and depletion of cellular antioxidants. Also, CCl4+ FSB-7 group showed minimal distortion in the histoarchitecture of liver and results were comparable to that of CCl4+ silymarin treated rats.
CONCLUSION: This inventory is the first scientific report on hepatoprotective potential of FSB methanolic extract.
MATERIALS AND METHODS: Activity levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and cell viability were evaluated in HepG2 cells treated with carbon tetrachloride (CCl4) in presence or absence of FL extracts or fractions. Also, plasma markers of hepatic damage, hepatic antioxidants, lipid peroxidation and histopathological alterations were assessed in rats treated with CCl4 alone or in combination with 200 or 400 mg/kg bodyweight (BW) of FSB-7 or 25 mg/kg BW of silymarin.
RESULTS: In vitro co-supplementation of FSB extracts or fractions recorded varying degree of hepatoprotective potentials. Also, pre-supplementation of FSB methanolic extract (FSB-7) followed by CCl4 treatment significantly prevented hepatic damage and depletion of cellular antioxidants. Also, CCl4+ FSB-7 group showed minimal distortion in the histoarchitecture of liver and results were comparable to that of CCl4+ silymarin treated rats.
CONCLUSION: This inventory is the first scientific report on hepatoprotective potential of FSB methanolic extract.
Предметные рубрики MeSH
Alanine TransaminaseAlkaline PhosphataseAnimalsAntioxidantsAspartate AminotransferasesBilirubinBiomarkersCarbon TetrachlorideCell SurvivalChemical and Drug Induced Liver InjuryCytoprotectionDisease Models, AnimalDose-Response Relationship, DrugHep G2 CellsHepatocytesHumansLipid PeroxidationLiverMaleMethanolOxidative StressPlant BarkPlant ExtractsPlants, MedicinalRatsRats, WistarRutaceaeSilymarinSolvents