Deutsche medizinische Wochenschrift (1946) · 1999
[A 51-year-old patient with arterial hypertension, respiratory insufficiency and polycythemia--an unusual cause of nocturnal sleep-associated breathing disorder].
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Krabbe C, Hammerer M, Kritzinger K
Аннотация
HISTORY AND ADMISSION FINDINGS: A 51-year-old man without significant previous illness presented with treatment-resistant arterial hypertension, dyspnoea, increased fatigue and headaches. Except for a florid face and fine tremor the physical examination was unremarkable.
INVESTIGATIONS: The chest x-ray showed pulmonary congestion. Blood gas analysis indicated respiratory alkalosis and hypoxaemia (pO2 65.2 mm Hg, pCO2 33.9 mm Hg, pH 7.46) and polycythaemia (haemoglobin 18.1 g/dl, haematocrit 53.5%). There was no evidence of an underlying cardiopulmonary disease. Sleep apnoea screening with an 8-channel recorder was compatible with the central sleep apnoea syndrome (apnoea/hypopnoea index 38/h).
TREATMENT AND COURSE: In the absence of neurological findings and an underlying medical condition the patient was again questioned. This revealed that in the previous 3 months he had been living and working as a waiter at a height of 3029 m above sea-level, without prior acclimatization. The symptoms and abnormal findings cleared up after a 6-week stay at 800 m.
CONCLUSION: At a time when people often quickly move between different altitudes, high-altitude sickness should be included in the differential diagnosis of respiratory failure and the central sleep apnoea syndrome.
INVESTIGATIONS: The chest x-ray showed pulmonary congestion. Blood gas analysis indicated respiratory alkalosis and hypoxaemia (pO2 65.2 mm Hg, pCO2 33.9 mm Hg, pH 7.46) and polycythaemia (haemoglobin 18.1 g/dl, haematocrit 53.5%). There was no evidence of an underlying cardiopulmonary disease. Sleep apnoea screening with an 8-channel recorder was compatible with the central sleep apnoea syndrome (apnoea/hypopnoea index 38/h).
TREATMENT AND COURSE: In the absence of neurological findings and an underlying medical condition the patient was again questioned. This revealed that in the previous 3 months he had been living and working as a waiter at a height of 3029 m above sea-level, without prior acclimatization. The symptoms and abnormal findings cleared up after a 6-week stay at 800 m.
CONCLUSION: At a time when people often quickly move between different altitudes, high-altitude sickness should be included in the differential diagnosis of respiratory failure and the central sleep apnoea syndrome.