Effect of corticosteroids on perinatal outcomes in preterm premature rupture of membranes.

This case control comparative study was done on 100 pregnant women both primi and multi with rupture membranes in two groups. These patients were admitted and treated in the Department of Obstetrics and Gynaecology in Sir Salimullah Medical College and Mitford Hospital, Dhaka, from July 2003 to December 2005. In this study, mean age of case group was 23.80 years (with corticosteroids) and 24.20 years in control group (without corticosteroids), with a range of 15-39 years. Here, out of 49 alive babies 15(30.82%) were affected by the consequences of PROM and birth process in case group and in control group, out of 48 alive babies 22(45.83%) were affected by the consequences of PROM and birth process. In corticosteroid group, 04 babies developed asphyxia & 05 developed neonatal sepsis otherwise in control group 08 babies developed asphyxia & 04 developed neonatal sepsis. So, on fetal outcome at this level in group with corticosteroids was better than without corticosteroids group. In this study, 12(24%) mother were affected by the consequences of PROM and corticosteroid therapy and majorities were chorioamnionitis (10%) and PPH (10%) and in control group 06(12%) were affected by the consequences of PROM and birth process. So, on maternal outcome at this level in control group (without corticosteroids) was better than case group. In this study effect of corticosteroids was evaluated on perinatal outcome in preterm premature rupture of membrane in developing country like Bangladesh & the effect of corticosteroids found better result on perinatal outcome but this apparent trend of the study could not be proved statistically.