The São Paulo declaration on One Health: Brazil's path forward to face intersectoral health challenges.

In 2024, Brazil reached significant milestones in advancing the One Health framework, notably with the establishment of the Interinstitutional Technical Committee for One Health and the launch of the São Paulo Declaration on One Health. These developments mark a crucial step forward in Brazil's strategy to address the interconnected challenges of human, animal, plant, and environmental health. The One Health framework underscores the need for cross-sectoral collaboration, transdisciplinary partnerships, and community-driven engagement, particularly as global issues such as climate change, ecosystem degradation, and health crises become increasingly urgent. The São Paulo Declaration advocates for integrated health surveillance, fostering intersectoral cooperation, and promoting sustainable practices to tackle emerging health threats. It calls for a unified approach to addressing climate change, biodiversity loss, and social vulnerability while prioritizing research, capacity building, and policy integration across all governance levels. This commentary highlights the importance of the São Paulo Declaration in advancing Brazil's One Health strategy and calls for sustained action from academia, governments, and society. These collective efforts are critical to ensuring a resilient and sustainable future, safeguarding the health of humans, animals, and the environment through holistic collaboration.