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DOI 10.1016/j.lansea.2025.100608

Медицинская библиотека · The Lancet regional health. Southeast Asia · 2025

Availability of anti-rabies vaccine and rabies immunoglobulin in Indian health facilities: a nationwide cross-sectional health facility survey.

Krishna Navaneeth S, Vivian Thangaraj Jeromie Wesley, Devika Shanmugasundaram, Sasi Aruna, Egambaram Suganya, Rani D Sudha, Khan Siraj Ahmed, Delli Anitha, Srivastava Ashok Kumar, Mishra Ayush, Shrinivasa Basavaraj, Pandiyan Chandhini, Gour Devendra, Purakayastha Debjani Ram, Verma Nirmal, Sharma Parul, Soni Ravinder Kumar, Ramasamy Sabarinatha, Mohandas K Sreelakshmi, Baidya Subrata, Rehman Tanveer, Yeldandi Vijay V, Singh Akashdeep, Sreedevi Aswathy, Tandale Babasaheb V, Durairajan Chokkalingam, Mahajan Hemant, Jain Kamlesh, Reddy Mahendra M, Toppo Manju, Solanki Nitinkumar Valjibhai, Ghosh Pramit, Vyas Shaili, Das Shampa, Palo Subrata Kumar, Prasanth Venela, Ali Atefh, Bathin Viswanath Guru, Sahu Dinesh Kumar, Rani G P Sabitha, Madhukar Major, Zaman Kamran, Pandey Krishna, Chander M Punnam, Kant Rajni, Varkey Reshmi Ann, Pati Sanghamitra, Agarwal Shailendra, Panwar Srashti, Menon Vishnu B, Vaman Raman Swathy, Velayudhan Anoop, Joy Sam, Rahi Manju, Murhekar Manoj V

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Аннотация

BACKGROUND

Ensuring the uninterrupted availability of the anti-rabies vaccine (ARV) and rabies immunoglobulin (RIG) in health facilities is crucial to achieve the global target of zero dog-mediated human rabies deaths by 2030. This study aimed to estimate the availability of ARV and RIG across health facilities in India.

METHODS

We conducted a nationwide health facility-based, cross-sectional study across 60 districts selected by multistage probability sampling from 15 Indian states. In each district, we selected nine health facilities. We interviewed staff involved in the rabies control program in each of the selected health facilities, and abstracted and physically validated information on the availability of ARV and RIG.

FINDINGS: Of the 534 health facilities surveyed, 467 (87.5%) were public sector health facilities. ARV was available in 372 (79.7%, 95% CI: 75.7%-83.2%) public sector health facilities, ranging from 60.0% to 93.2% in different geographic regions. Availability of ARV was lowest in Urban Primary Healthcare Centres (UPHCs) (58.9%, 95% CI: 45.0%-71.9%). RIG was available in 95 (20.3%, 95% CI: 16.8%-24.3%) public sector health facilities, with the highest availability in southern states (27/88, 30.7%). The availability of RIG ranged from 1.8% (95% CI: 16.8%-24.3%) in UPHCs to 69.2% (95% CI: 48.2%-85.7%) in medical college hospitals.

INTERPRETATION: Considerable geographic and facility-level variations exist in the availability of ARV and RIG across India. Bridging the gap in the availability of ARV and RIG should be prioritised to achieve the goal of zero-dog-mediated human rabies deaths by 2030.

FUNDING: Indian Council of Medical Research.

Для цитирования: Krishna Navaneeth S, Vivian Thangaraj Jeromie Wesley, Devika Shanmugasundaram, Sasi Aruna, Egambaram Suganya, Rani D Sudha, Khan Siraj Ahmed, Delli Anitha, Srivastava Ashok Kumar, Mishra Ayush, Shrinivasa Basavaraj, Pandiyan Chandhini, Gour Devendra, Purakayastha Debjani Ram, Verma Nirmal, Sharma Parul, Soni Ravinder Kumar, Ramasamy Sabarinatha, Mohandas K Sreelakshmi, Baidya Subrata, Rehman Tanveer, Yeldandi Vijay V, Singh Akashdeep, Sreedevi Aswathy, Tandale Babasaheb V, Durairajan Chokkalingam, Mahajan Hemant, Jain Kamlesh, Reddy Mahendra M, Toppo Manju, Solanki Nitinkumar Valjibhai, Ghosh Pramit, Vyas Shaili, Das Shampa, Palo Subrata Kumar, Prasanth Venela, Ali Atefh, Bathin Viswanath Guru, Sahu Dinesh Kumar, Rani G P Sabitha, Madhukar Major, Zaman Kamran, Pandey Krishna, Chander M Punnam, Kant Rajni, Varkey Reshmi Ann, Pati Sanghamitra, Agarwal Shailendra, Panwar Srashti, Menon Vishnu B, Vaman Raman Swathy, Velayudhan Anoop, Joy Sam, Rahi Manju, Murhekar Manoj V. Availability of anti-rabies vaccine and rabies immunoglobulin in Indian health facilities: a nationwide cross-sectional health facility survey.. The Lancet regional health. Southeast Asia. 2025. DOI: 10.1016/j.lansea.2025.100608.
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