Fertility and sterility · 2009
Beneficial effect of autologous endometrial cell coculture in patients with repeated implantation failure.
Контролируемое клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Eyheremendy Victoria, Raffo Fernanda G E, Papayannis Mercedes, Barnes Julia, Granados Cintia, Blaquier Jorge
Аннотация
OBJECTIVE: To confirm the beneficial effect of endometrial coculture in patients with repeated failures with assisted reproductive techniques (ART).
DESIGN: Patients with previous failures were offered a repetition of ART in conjunction with autologous endometrial coculture.
SETTING: Private fertility center.
PATIENT(S): Sixty-eight couples who had attempted 92 cycles of IVF or intracytoplasmic sperm injection without obtaining an evolutive pregnancy.
INTERVENTION(S): Patients repeated one cycle of ART with concomitant endometrial coculture of their embryos.
MAIN OUTCOME MEASURES(S): Comparative pregnancy and delivery rates in conventional ART cycles vs. cycles with autologous endometrial coculture.
RESULT(S): In the previous 92 cycles (146 ETs, fresh plus frozen) only 8 pregnancies were initiated, and all ended in spontaneous abortion. Upon repeating 68 cycles (76 ETs) using coculture, 39 pregnancies were obtained, of which 19 resulted in live births, 10 are ongoing evolutive pregnancies, and 10 ended in spontaneous abortions.
CONCLUSION(S): These results confirm the usefulness of autologous endometrial coculture for the treatment of patients with repeated implantation failure.
DESIGN: Patients with previous failures were offered a repetition of ART in conjunction with autologous endometrial coculture.
SETTING: Private fertility center.
PATIENT(S): Sixty-eight couples who had attempted 92 cycles of IVF or intracytoplasmic sperm injection without obtaining an evolutive pregnancy.
INTERVENTION(S): Patients repeated one cycle of ART with concomitant endometrial coculture of their embryos.
MAIN OUTCOME MEASURES(S): Comparative pregnancy and delivery rates in conventional ART cycles vs. cycles with autologous endometrial coculture.
RESULT(S): In the previous 92 cycles (146 ETs, fresh plus frozen) only 8 pregnancies were initiated, and all ended in spontaneous abortion. Upon repeating 68 cycles (76 ETs) using coculture, 39 pregnancies were obtained, of which 19 resulted in live births, 10 are ongoing evolutive pregnancies, and 10 ended in spontaneous abortions.
CONCLUSION(S): These results confirm the usefulness of autologous endometrial coculture for the treatment of patients with repeated implantation failure.