Infectious diseases & clinical microbiology · 2023
Factors Associated with 28-day Critical Illness Development During the First Wave of COVID-19.
СтатьяНазвание и аннотация: Перевод в очереди
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Sili Uluhan, Ay Pınar, Bilgin Hüseyin, Topuzoğlu Ahmet, Tükenmez-Tigen Elif, Ertürk-Şengel Buket, Yağçı-Çağlayık Dilek, Balcan Baran, Kocakaya Derya, Olgun-Yıldızeli Şehnaz, Gül Fethi, Bilgili Beliz, Can-Sarınoğlu Rabia, Karahasan-Yağcı Ayşegül, Mülazimoğlu-Durmuşoğlu Lütfiye, Eryüksel Emel, Odabaşı Zekaver, Direskeneli Haner, Karakurt Sait, Korten Volkan
Аннотация
OBJECTIVE: This study aimed to define the predictors of critical illness development within 28 days postadmission during the first wave of the COVID-19 pandemic.
MATERIALS AND METHODS: We conducted a prospective cohort study including 477 PCR-positive COVID-19 patients admitted to a tertiary care hospital in Istanbul from March 12 to May 12, 2020.
RESULTS: The most common presenting symptoms were cough, dyspnea, and fatigue. Critical illness developed in 45 (9.4%; 95% CI=7.0%-12.4%) patients. In the multivariable analysis, age (hazard ratio (HR)=1.05, p<0.001), number of comorbidities (HR=1.33, p=0.02), procalcitonin ≥0.25 µg/L (HR=2.12, p=0.03) and lactate dehydrogenase (LDH) ≥350 U/L (HR=2.04, p=0.03) were independently associated with critical illness development. The World Health Organization (WHO) ordinal scale for clinical improvement on admission was the strongest predictor of critical illness (HR=4.15, p<0.001). The patients hospitalized at the end of the study period had a much better prognosis compared to the patients hospitalized at the beginning (HR=0.14; p=0.02). The C-index of the model was 0.92.
CONCLUSION: Age, comorbidity number, the WHO scale, LDH, and procalcitonin were independently associated with critical illness development. Mortality from COVID-19 seemed to be decreasing as the first wave of the pandemic advanced.
GRAPHIC ABSTRACT: Graphic Abstract.
MATERIALS AND METHODS: We conducted a prospective cohort study including 477 PCR-positive COVID-19 patients admitted to a tertiary care hospital in Istanbul from March 12 to May 12, 2020.
RESULTS: The most common presenting symptoms were cough, dyspnea, and fatigue. Critical illness developed in 45 (9.4%; 95% CI=7.0%-12.4%) patients. In the multivariable analysis, age (hazard ratio (HR)=1.05, p<0.001), number of comorbidities (HR=1.33, p=0.02), procalcitonin ≥0.25 µg/L (HR=2.12, p=0.03) and lactate dehydrogenase (LDH) ≥350 U/L (HR=2.04, p=0.03) were independently associated with critical illness development. The World Health Organization (WHO) ordinal scale for clinical improvement on admission was the strongest predictor of critical illness (HR=4.15, p<0.001). The patients hospitalized at the end of the study period had a much better prognosis compared to the patients hospitalized at the beginning (HR=0.14; p=0.02). The C-index of the model was 0.92.
CONCLUSION: Age, comorbidity number, the WHO scale, LDH, and procalcitonin were independently associated with critical illness development. Mortality from COVID-19 seemed to be decreasing as the first wave of the pandemic advanced.
GRAPHIC ABSTRACT: Graphic Abstract.