Pharmacology research & perspectives · 2020
The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Braga Cássia L, Silva-Aguiar Rodrigo P, Battaglini Denise, Peruchetti Diogo B, Robba Chiara, Pelosi Paolo, Rocco Patricia R M, Caruso-Neves Celso, Silva Pedro L
Аннотация
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS-CoV-2 and SARS-CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID-19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID-19 and potential therapeutic targets, focusing on the role of the renin-angiotensin-aldosterone system.
Предметные рубрики MeSH
Angiotensin Receptor AntagonistsAngiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsAnimalsAntiviral AgentsBetacoronavirusCOVID-19Coronavirus InfectionsEvidence-Based MedicineHost-Pathogen InteractionsHumansPandemicsPeptidyl-Dipeptidase APneumonia, ViralRenin-Angiotensin SystemSARS-CoV-2COVID-19 Drug Treatment