Journal of inorganic biochemistry · 2005
Synthesis, characterization, and antibacterial activity of three palladium(II) complexes of tetracyclines.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Guerra Wendell, de Andrade Azevedo Elaine, de Souza Monteiro Ana Raquel, Bucciarelli-Rodriguez Mônica, Chartone-Souza Edmar, Nascimento Andréa Maria Amaral, Fontes Ana Paula Soares, Le Moyec Laurence, Pereira-Maia Elene C
Аннотация
Pd(II) complexes with three antibiotics of the tetracycline family (tetracycline, doxycycline and chlortetracycline) were synthesized and characterized by elemental, thermogravimetric, and conductivity analyses, and infrared spectroscopy. The interactions between Pd(II) ions and tetracycline were investigated in aqueous solution by (1)H NMR. All the tetracyclines studied form 1:1 complexes with Pd(II) via the oxygen of the hydroxyl group at ring A and that of the amide group. The effect of the three complexes on the growth of bacterial strains sensitive and resistant to tetracycline was studied. The Pd(II) complex of tetracycline is practically as efficient as tetracycline in inhibiting the growth of two Escherichia coli (E. coli) sensitive bacterial strains and 16 times more potent against E. coli HB101/pBR322, a bacterial strain resistant to tetracycline. Pd(II) coordination to doxycycline also increased its activity in the resistant strain by a factor of 2.