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DOI 10.1016/j.clim.2014.02.013

Медицинская библиотека · Clinical immunology (Orlando, Fla.) · 2014

The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy.

Junge Kristin M, Hörnig Friederike, Herberth Gunda, Röder Stefan, Kohajda Tibor, Rolle-Kampczyk Ulrike, von Bergen Martin, Borte Michael, Simon Jan-Christoph, Heroux Delia, Denburg Judah A, Lehmann Irina

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

RATIONALE: Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment.

METHODS

In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation.

RESULTS

Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months.

CONCLUSIONS

The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.

Для цитирования: Junge Kristin M, Hörnig Friederike, Herberth Gunda, Röder Stefan, Kohajda Tibor, Rolle-Kampczyk Ulrike, von Bergen Martin, Borte Michael, Simon Jan-Christoph, Heroux Delia, Denburg Judah A, Lehmann Irina. The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy.. Clinical immunology (Orlando, Fla.). 2014. DOI: 10.1016/j.clim.2014.02.013.

Предметные рубрики MeSH

BasophilsCell DifferentiationCohort StudiesEnvironmental ExposureEosinophilsFemaleFetal BloodFetal Stem CellsHumansInfantInfant, NewbornMalePregnancyPrenatal Exposure Delayed EffectsRespiratory Tract InfectionsSurveys and QuestionnairesTh1-Th2 BalanceVolatile Organic Compounds
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