[Cooperation between the urologist and microbiologist in the diagnosis and treatment of sepsis. II. The most common microbial species and their sensitivity to antimicrobial drugs in sepsis at the Urologic Clinic of the Medical School Hospital].

The authors investigated the spectrum of aetiological agents and their sensitivity to antimicrobial substances in 52 patients with septicaemia at the Urological Clinic in Hradec Králové during 1984-1987. They found a predominating number of Gram-negative bacteria (82%). The most frequent agent producing sepsis was Klebsiella pneumoniae (19X), its source were in 52% the urinary pathways and 16% the cannula in the subclavian vein. In nine instances the aetiological agent was Escherichia coli and 5 times Proteus mirabilis. The above microorganisms are the most important pathogenic organisms of the urinary pathways. In all cases of bacteriaemia urosepsis was involved. The source of sepsis caused by Pseudomonas aeruginosa (7X) was in 43% the urinary tract, in particular in conjunction with instrumental procedures and in 14% a cannula in the subclavian vein. The most effective antimicrobial substance in Gram-negative bacteraemia in the investigated group was amicacin (100%); high sensitivity was recorded also in colistin. In Gram-positive bacteriaemia, where most frequently enterococci were isolated (6X), ampicillin and vancomycin were most effective.