Le Mali medical · 2017
[High prevalence of methicillin-resistant Staphylococcus aureus strains in the Point G teaching hospital in Bamako, Mali].
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Maïga A, Dicko O A, Tchougoune L M, Fofana D B, Coulibaly D M, Maïga I I
Аннотация
UNLABELLED: Our aim was to study the susceptibility of Staphylococcus aureus to antimicrobial agents and to determine the methicillin-resistant S. aureus (MRSA) prevalence in the Point G teaching hospital in Bamako.
METHODS: Columbia blood agar with nalidixic acid and colistin was used for the isolation of S. aureus strains. The diffusion method was used for antimicrobial susceptibility testing.
RESULTS: Of 434 non repetitive strains of S. aureus isolated from 2007 to 2009 in the Point G teaching hospital, 297 (68.6%) were from hospital area and 137 (31.4%) were from extra-hospital area. The hospital strains were more resistant to penicillin than the extra-hospital strains (95% versus 88%; p = 0,016). Tetracycline was more active against hospital clinical isolates than extra-hospital clinical isolates (32% versus 21%; p = 0.024). Among 297 S. aureus clinical isolates, 195 (66%) were MRSA and 102 (34%) were methicillin-susceptible S. aureus (MSSA). The MRSA clinical isolates prevalence was higher in hospital area than in extra-hospital area (66% versus 55.5%; p = 0.0418). The MRSA clinical isolates prevalence was higher in the medical wards than in the surgical wards (74.8% vs 34.3%; p < 10-6). Among 251 MRSA clinical isolates, 169 (67.3%) were from urine, 39 (15.5%) from pus, 30 (12%) from blood culture, 7 (2.9%) from vagina and 6 (2.5%) from other sites. The MRSA clinical isolates prevalence was 46% in 2007, 63% in 2008 and 80% in 2009. The MRSA clinical isolates were highly more resistant to penicillin (p < 10-6), to amoxicillin combined with clavulanic acid (p < 10-6), to aminoglycosides (p < 10-6), to macrolides, lincosamides and streptogramins (p < 10-6), to norfloxacin (p < 10-6), to chloramphenicol (p < 10-6), to tetracycline (p = 0,0042), to sulfonamides (p < 10-6), to trimethoprim (p < 10-6), to fusidic acid (p < 10-6), and to fosfomycin (p = 0,0103) than the MSSA strains. The high level resistance to aminoglycosides, fluoroquinolones, macrolides, lincosamides and streptogramins was more frequent in the MRSA strains than in the MSSA strains.
CONCLUSION: The MRSA clinical isolates prevalence was very high in the Point G teaching hospital in Bamako, in the medical wards especially. The MRSA strains were drugs multiple resistant.
METHODS: Columbia blood agar with nalidixic acid and colistin was used for the isolation of S. aureus strains. The diffusion method was used for antimicrobial susceptibility testing.
RESULTS: Of 434 non repetitive strains of S. aureus isolated from 2007 to 2009 in the Point G teaching hospital, 297 (68.6%) were from hospital area and 137 (31.4%) were from extra-hospital area. The hospital strains were more resistant to penicillin than the extra-hospital strains (95% versus 88%; p = 0,016). Tetracycline was more active against hospital clinical isolates than extra-hospital clinical isolates (32% versus 21%; p = 0.024). Among 297 S. aureus clinical isolates, 195 (66%) were MRSA and 102 (34%) were methicillin-susceptible S. aureus (MSSA). The MRSA clinical isolates prevalence was higher in hospital area than in extra-hospital area (66% versus 55.5%; p = 0.0418). The MRSA clinical isolates prevalence was higher in the medical wards than in the surgical wards (74.8% vs 34.3%; p < 10-6). Among 251 MRSA clinical isolates, 169 (67.3%) were from urine, 39 (15.5%) from pus, 30 (12%) from blood culture, 7 (2.9%) from vagina and 6 (2.5%) from other sites. The MRSA clinical isolates prevalence was 46% in 2007, 63% in 2008 and 80% in 2009. The MRSA clinical isolates were highly more resistant to penicillin (p < 10-6), to amoxicillin combined with clavulanic acid (p < 10-6), to aminoglycosides (p < 10-6), to macrolides, lincosamides and streptogramins (p < 10-6), to norfloxacin (p < 10-6), to chloramphenicol (p < 10-6), to tetracycline (p = 0,0042), to sulfonamides (p < 10-6), to trimethoprim (p < 10-6), to fusidic acid (p < 10-6), and to fosfomycin (p = 0,0103) than the MSSA strains. The high level resistance to aminoglycosides, fluoroquinolones, macrolides, lincosamides and streptogramins was more frequent in the MRSA strains than in the MSSA strains.
CONCLUSION: The MRSA clinical isolates prevalence was very high in the Point G teaching hospital in Bamako, in the medical wards especially. The MRSA strains were drugs multiple resistant.