Seminars in thrombosis and hemostasis · 2024
Risk Factors for Antiphospholipid Antibodies and Antiphospholipid Syndrome.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Aguirre Del-Pino Rodrigo, Monahan Rory C, Huizinga Tom W J, Eikenboom Jeroen, Steup-Beekman Gerda M
Аннотация
Persistence of serum antiphospholipid antibodies (aPL) is associated with a high thrombotic risk, both arterial and venous, and with pregnancy complications. Due to the potential morbidity and mortality associated with the presence of aPL, identifying and recognizing risk factors for the development of aPL and thrombosis in aPL carriers may help to prevent and reduce the burden of disease. Multiple elements are involved in the pathomechanism of aPL development and aPL-related thrombosis such as genetics, malignancy, and infections. This review will address the role of both well-known risk factors and their evolution, and of emerging risk factors, including COVID-19, in the development of aPL and thrombosis in aPL carriers.