Revista espanola de fisiologia · 1989
Alterations in the nuclear volume of neurones from the hypothalamic magnocellular nuclei of fetuses born to rats subject to chronic alcoholism.
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Fresnillo M, Villa-Elízaga I, Olazabal A, Frizell E, López de Ochoa J A, Ballesteros A, Sierrasesúmaga L
Аннотация
Previous authors have noticed alterations of the neuroendocrine system in the offspring of chronically alcoholic animals. Forty Sprague-Dawley rats, were used fed a liquid control diet and a 5%-alcohol liquid diet (Lieber and DeCarli). They were divided into four groups: Control (C), Pair Fed (P), Embryonic alcohol (E) and Fetal alcohol (F). Results obtained in the statistical analysis were as follows: from the paraventricular nucleus: between E and F, E and P, E and C, p less than 0.001. F and C p less than 0.01. P and C p less than 0.005. Between F and P there were no significant differences. From the supraoptic nucleus: E and P, E and C p less than 0.001. F and P p less than 0.025, F and C p less than 0.01. Between E and F, P and C there were no significant differences.