American journal of Alzheimer's disease and other dementias · 2012
Gene-environment interaction in Alzheimer's disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Singh Neeraj Kumar, Chhillar Neelam, Banerjee B D, Bala Kiran, Mukherjee Ajit Kumar, Mustafa M D, Mitrabasu
Аннотация
OBJECTIVES: The aim was to examine the gene environment (GxE) interaction with reference to APO E genotypes, serum lipids and organochlorine pesticides (OCPs) as one of the factors in the etiology of Alzheimer's disease (AD).
METHODS: A case control study was used to examine, APOE HhaI polymorphism by polymerase chain reaction (PCR)/PCRrestriction fragment length polymorphism method, serum lipids by autoanalyser and OCPs by gas chromatography (GC).
RESULTS: APOE ∈4 allele frequency was significantly high (p=0.000, OR=5.73, CI=2.68-12.50) in AD as compared to controls. The serum cholesterol, β- hexachlorocyclohexane and dieldrin are risk factors for AD independent of the APOE ∈4 risk allele, recording an odds ratio of 1.16, 11.38 and 10.45 respectively.
CONCLUSION: GxE interactions exist with APOE ∈4 allele status that need to be considered for the study design and analysis of such data in future studies of AD.
METHODS: A case control study was used to examine, APOE HhaI polymorphism by polymerase chain reaction (PCR)/PCRrestriction fragment length polymorphism method, serum lipids by autoanalyser and OCPs by gas chromatography (GC).
RESULTS: APOE ∈4 allele frequency was significantly high (p=0.000, OR=5.73, CI=2.68-12.50) in AD as compared to controls. The serum cholesterol, β- hexachlorocyclohexane and dieldrin are risk factors for AD independent of the APOE ∈4 risk allele, recording an odds ratio of 1.16, 11.38 and 10.45 respectively.
CONCLUSION: GxE interactions exist with APOE ∈4 allele status that need to be considered for the study design and analysis of such data in future studies of AD.
Предметные рубрики MeSH
AgedAged, 80 and overAlzheimer DiseaseApolipoprotein E4Case-Control StudiesCholesterolChromatography, GasDieldrinEnvironmental ExposureFemaleGene FrequencyGene-Environment InteractionGenetic Predisposition to DiseaseHexachlorocyclohexaneHumansHydrocarbons, ChlorinatedLipoproteins, HDLLipoproteins, LDLLogistic ModelsMaleMiddle AgedOdds RatioPesticidesPolymorphism, GeneticRisk FactorsTriglycerides