End-Stage Chronic Kidney Disease Affects Serum Nostrin Turnover.

INTRODUCTION

Serum Nostrin was recently identified as novel predictor of important clinical outcomes in acute kidney injury (AKI) and has also emerged as a predictor of recovery of kidney function (ROKF) in AKI patients. ROKF is a critical factor for the transition of AKI into chronic kidney disease (CKD). Therefore the aim of the present study was to evaluate serum Nostrin levels in CKD patients.

METHODS

Blood samples were collected from CKD patients before and after dialysis, and serum Nostrin levels were determined using ELISAs.

RESULTS

Serum Nostrin levels were previously shown to be significantly increased in AKI patients in comparison with healthy controls. In CKD patients, the levels of serum Nostrin were further increased without significant differences of Nostrin concentrations before and after dialysis.

CONCLUSION

The further elevation of serum Nostrin concentrations in CKD in comparison with AKI indicates a significant impairment of Nostrin turnover and supports the possible suitability of Nostrin as potential diagnostic value in both AKI and CKD.