Journal of hepato-biliary-pancreatic sciences · 2016
Outcomes after resection of occupational cholangiocarcinoma.
СтатьяНазвание и аннотация: Перевод в очереди
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Kubo Shoji, Takemura Shigekazu, Tanaka Shogo, Shinkawa Hiroji, Kinoshita Masahiko, Hamano Genya, Ito Tokuji, Koda Masaki, Aota Takanori, Yamamoto Takatsugu, Terajima Hiroaki, Tachiyama Gorou, Yamada Terumasa, Nakamori Shoji, Arimoto Akira, Fujikawa Masahiro, Tomimaru Yoshito, Sugawara Yasuhiko, Nakagawa Kei, Unno Michiaki, Mizuguchi Toru, Takenaka Kenji, Kimura Koichi, Shirabe Ken, Saiura Akio, Uesaka Katsuhiko, Taniguchi Hiroki, Fukuda Akira, Chong Ja-Mun, Kuwae Yuko, Ohsawa Masahiko, Sato Yasunori, Nakanuma Yasuni
Аннотация
BACKGROUND: Cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane is recognized as occupational cholangiocarcinoma. The aim of this study was to investigate the outcomes after resection of occupational cholangiocarcinoma to establish a treatment strategy for this disease.
METHODS: Clinicopathological findings and outcomes after surgical intervention in 20 patients with occupational cholangiocarcinoma were investigated.
RESULTS: Of 20 the patients, curative resection was performed in 16 patients. Three patients underwent radiation at the stump of the bile ducts. Adjuvant chemotherapy was performed in 12 patients. Biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, and/or chronic bile duct injury was detected in most subjects. Intraabdominal infection developed after surgery in nine patients. Cholangiocarcinoma recurred in 12 of the 20 patients. The recurrent tumors in five patients developed at a different part of the bile duct from the primary tumor and a second resection was performed in four of these five patients.
CONCLUSIONS: The incidence of postoperative complications including intraabdominal infection was high in patients with occupational cholangiocarcinoma. Multicentric recurrence occurred not infrequently after surgery because the bile ducts had a high potential for the development of carcinoma. The aggressive treatment including second resection for the multicentric recurrence appeared to be effective.
METHODS: Clinicopathological findings and outcomes after surgical intervention in 20 patients with occupational cholangiocarcinoma were investigated.
RESULTS: Of 20 the patients, curative resection was performed in 16 patients. Three patients underwent radiation at the stump of the bile ducts. Adjuvant chemotherapy was performed in 12 patients. Biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, and/or chronic bile duct injury was detected in most subjects. Intraabdominal infection developed after surgery in nine patients. Cholangiocarcinoma recurred in 12 of the 20 patients. The recurrent tumors in five patients developed at a different part of the bile duct from the primary tumor and a second resection was performed in four of these five patients.
CONCLUSIONS: The incidence of postoperative complications including intraabdominal infection was high in patients with occupational cholangiocarcinoma. Multicentric recurrence occurred not infrequently after surgery because the bile ducts had a high potential for the development of carcinoma. The aggressive treatment including second resection for the multicentric recurrence appeared to be effective.
Предметные рубрики MeSH
AdultBile Duct NeoplasmsBiliary Tract Surgical ProceduresBiopsy, NeedleCholangiocarcinomaCohort StudiesDisease-Free SurvivalFemaleHumansImmunohistochemistryJapanMaleMethylene ChlorideMiddle AgedOccupational DiseasesOccupational ExposurePrognosisRetrospective StudiesRisk AssessmentSurvival RateTreatment Outcome