[Effects of XW630 on the expression of type I collagen protein in the epiphyseal plates of mice].

OBJECTIVE

To identify the effect of XW630 on the expression of type I collagen in the epiphyseal plates of mice.

METHODS

The immunohistochemical method was used to measure the change of type I collagen protein after being treated with XW630.

RESULTS

With 10(-7) mol/L or 10(-7) mol/L of XW630, the area of positive stain cells in every zone increased significantly compared to the control group. A more significant increase of the area of positive cells in the proliferative zone and hypertrophic zone was observed in the XW630 group than in the estrone group at a concentration of 10(-7) mol/L. When the XW630 was decreased to 10(-9) mol/L, the increase of positive cells was only found in the hypertrophic zone. The area of positive cells increased with the concentration of XW630.

CONCLUSION

The XW630 upregulates the dose-dependent expression of type I collagen protein in the resting zone, proliferative zone, and hypertrophic zone in the epiphyseal plates of mice in vitro.