Partial metabolic inhibition stimulates adrenal medullary secretion possibly by activating Na-dependent Ca influx mechanism.

The rabbit adrenal gland perfused throughout with a Ca-deficient, Mg-containing medium becomes responsive to a challenge with Ca (2 mM) re-introduction after treatment with cyanide, 2-deoxy-glucose plus glucose deprivation or monoiodoacetate. The results suggest that the partial metabolic inhibition leads to the reduced activity of Na pumping, thereby activating Na-dependent Ca influx mechanism.