[Cutaneous lesion of adult T-cell lymphoma treated successfully with local hyperthermia in combination with intravenous administration of rINF-gamma].

Cutaneous lesions of adult T-cell lymphoma on the bilateral temples in a 74-year-old male were treated either with rINF-gamma and local hyperthermia or rIFN-gamma alone. The size of the tumor on the left temple was reduced by 40% 10 days after the therapy was initiated by the intravenous administration of rIFN-gamma (2 X 10(5) - 4 X 10(5) JRU/day, total 1 X 10(7) JRU) and local hyperthermia (6 times). The tumor had almost disappeared after 21 days (total dose of rIFN-gamma, 3.4 X 10(7) JRU; hyperthermia, 13 times). Two cutaneous tumors on the right temple had rapidly reduced in size 17 days after the therapy of rIFN-gamma was started. The sizes of the lesions had decreased by 79% on day 17 and had further decreased by 91% and 95% on day 21, respectively. All lesions were irradiated with Dermopan for the prevention of recurrence. Local hyperthermia in combination with rIFN-gamma seems to be useful for the treatment of cutaneous lesions of malignant lymphoma.