Internal medicine (Tokyo, Japan) · 2010
Primary ciliary dyskinesia that responded to long-term, low-dose clarithromycin.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Yoshioka Daisuke, Sakamoto Noriho, Ishimatsu Yuji, Kakugawa Tomoyuki, Ishii Hiroshi, Mukae Hiroshi, Kadota Jun-Ichi, Kohno Shigeru
Аннотация
A 46-year-old man was referred to our hospital with hemoptysis. He had been diagnosed with chronic sinusitis since childhood, but had received no treatment. Chest CT showed a diffuse centrilobular granular shadow and thickened bronchial walls. Otitis media and decreased spermatic motor ability were identified. In addition, electron microscopy of a biopsy specimen of the nasal mucosa showed a deficiency of inner dynein. Based on these clinical findings, primary ciliary dyskinesia (PCD) was diagnosed and successfully treated with long-term, low-dose clarithromycin. Although the effects of macrolide therapy remain controversial, long-term treatment with low-dose clarithromycin might confer clinical benefits upon patients with PCD.